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Tosoh Bioscience LLC: The Chemistry of Innovation
Process Development Products
Resin Screening
Method Optimization
Scalability
Ordering Information

Initial results from resin screening and optimization with ToyoScreen columns can accurately predict the separation behavior at larger scales. The figure to the right illustrates the similar retention time behavior between 1mL ToyoScreen columns and conventional 7.5mmID x 7.5cm analytical columns. Additionally, the figure below depicts a practical antibody scale up in which conditions were set using a 1mL ToyoScreen and applied to a 10mL semi-preparative column with a different inner diameter and length. Similar resolution results were predicted by the following equation:

scale-up formula

Selectivity comparison between ToyoScreen and Conventional column

Comparison of selectivity 

   
Comparison chromatograms between ToyoScreen and Semi-preparative columns

Scale-up 



Contact us:

Tech Service:
800-366-4875 (option #3)

Customer Service:
866-527-3587

info.tbl@tosoh.com
 


ToyoScreen Instruction Manual

Brochure -- ToyoScreen Process Development Columns

Catalog -- Complete 2012-13 Process Media

Technical Presentation -- Resin-Screening and Method Development with Pre-Packed Process Development Columns

Return to ToyoScreen main page

Tosoh Bioscience LLC 3604 Horizon Drive, Suite 100, King of Prussia, PA, 19406 Tel: (800) 366-4875  Email: info.tbl@tosoh.com