Toyopearl PPG-600 (polypropylene glycol) has the second highest hydrophilicity of the HIC ligands offered by TBL. It has been optimized for the purification of monoclonal antibodies and is used as an intermediate purification or polishing step. It has extremely good capacity and recovery for mAbs.

Structure:

Hydrophobicity:

Ether < PPG < Phenyl < Butyl < Hexyl
(least to most)

Product Attributes:

Pore size (mean):  750 Å  Particle size (mean):  65µm (M-grade)   Pressure rating:  3 bar  Shipping buffer:  20% ethanol  pH stability:  1-13  Shelf life:  10 years

Literature:

Catalog - Process Media, Hydrophobic Interaction Chromatography

Product Overview -- Toyopearl PPG-600M, for Hydrophobic Interaction Chromatography of Monoclonal Antibodies, Hydrophobic Proteins and Pegylated Targets

Technical Presentation -- Purification of monoclonal antibodies using new pore size optimized HIC resins