Toyopearl GigaCap CM-650 media is a high capacity cation exchange resin* optimized specifically for high throughput purification of IgG. Toyopearl HW-65 resin is the polymeric base bead, which is chemically modified to provide a high level of cationic binding sites for IgG. It exhibits typical dynamic binding capacities in the vicinity of 100 mg/mL for IgG. This new polymer product is stable at high linear velocities, has good pressure flow characteristics and will withstand back pressures up to 3 bar. The new higher capacity and back pressure stability of Toyopearl GigaCap CM-650 resin creates opportunities for increased throughput in downstream cation exchange purification steps.
Toyopearl GigaCap CM-650 resin has a different selectivity than Toyopearl GigaCap S-650 resin. With its unusually high capacity for a weak cationic exchange resin this selectivity may be exploited for either mAb or traditional protein purifications.
Toyopearl GigaCap CM-650 media also has excellent base stability in 0.5mol/L NaOH.
*specifically designed for packed bed use
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