Through combinatorial libraries, phage display, or other means, customers may identify an affinity ligand suitable for their target molecule. There are a number of Toyopearl resins available with chemistries (shown below) for special ligand immobilization:

The development of a specialized affinity resin is a challenging task. The affinity ligand must be immobilized so as not to interfere with its binding chemistry for the target. The ligand's spatial orientation away from the bead surface needs to be engineered appropriately, and different ligand densities must be evaluated to prevent or control multipoint attachments of an individual target protein.

Tosoh can utilize its extensive ligand attachment expertise to create a novel affinity resin for your process.. The primary customer requirement is to provide a source for sufficient quantities of the desired ligand to Tosoh.

Click here to start a TRIP request with us.