(Each issue we will print some of the questions we receive in our Technical Services Group. Feel free to email us your question and be and check out our extensive FAQ pages.
Question: “How can you tell when it is time to change your guard column?”
Answer: Unfortunately guard columns are not like light bulbs that burn out when it is time to change them. It is best to get into a routine of changing guard columns on a regular basis like you would a water filter. Tosoh recommends replacing guard cartridges after every 30 to 40 injections although this frequency can vary depending on the column and type of samples being injected.
Signs that might indicate a need to change the guard column are higher than usual back pressure, peak broadening, changes in selectivity or changes in retention time.
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