TOYOPEARL GigaCap CM-650M resin is a high capacity cation exchange resin optimized for the high throughput purification of IgG’s.  The resins are composed of a base material of hydroxylated methacrylic polymer beads that have been chemically modified to provide a higher number of cationic binding sites and functionalized with carboxymethyl (CM) weak cation exchange groups.

TOYOPEARL GigaCap CM-650M resin exhibits different selectivity than the TOYOPEARL GigaCap S-650 resin. This difference, combined with its unusually high capacity for a weak cation exchange resin, may be exploited for either mAb or traditional protein purifications. TOYOPEARL GigaCap CM-650 resin is available in one particle size, 75 µm, which corresponds to the M-grade designation for TOYOPEARL resins.

TOYOPEARL GigaCap CM-650M exhibits typical dynamic binding capacities of 100 g/L for human IgG, maintains high capacity at increased linear velocities, has good pressure-flow characteristics, and will withstand back pressures up to 0.3 MPa.  

TOYOPEARL GigaCap CM-650M media has excellent binding and elution kinetics, which results in a more concentrated protein fraction collected during the elution step. TOYOPEARL GigaCap CM-650M media also has excellent caustic stability in 0.5 mol/L NaOH.