TOYOPEARL CM-650C resin is a weak cation exchanger for biomolecule purification. The resin is composed of a base material of hydroxylated methacrylic polymer beads that have been functionalized with carboxymethyl (CM) weak cation exchange groups.  TOYOPEARL CM-650C has a high degree of chemical and mechanical stability, allowing cleaning-in-place (CIP) and very high flow rates.

TOYOPEARL CM-650C has a 100 nm pore size and a 100 µm bead size and can be used for high throughput capture, intermediate purification, and polishing process steps.  If greater resolution is needed, the smaller particle TOYOPEARL CM-650M or TOYOPEARL CM-650S resins may be used.

TOYOPEARL CM-650C has a dynamic binding capacity for lysozyme of 35 g/L. TOYOPEARL CM-650C maintains capacity at increased linear velocities, has good pressure-flow characteristics, and will withstand back pressures up to 0.3 MPa.