Process Media


TOYOPEARL MegaCap II SP-550EC resin is a high capacity cation exchange resins optimized for the capture and purification of small peptides such as insulin and proteins up to 100 kDa.  This resin is composed of a base material of hydroxylated methacrylic polymer beads that have been functionalized with sulfopropyl (S) strong cation exchange groups.

TOYOPEARL MegaCap II SP-550EC resin can be used for high throughput capture and intermediate purification process steps. TOYOPEARL MegaCap II SP-550EC resin is available in one particle size, 200 µm, which corresponds to the EC-grade.

TOYOPEARL MegaCap II SP-550EC exhibits typical dynamic binding capacities in the vicinity of 130 g/L for insulin, maintains high capacity at increased linear velocities, has good pressure-flow characteristics, and will withstand back pressures up to 0.3 MPa.  


P/NDescriptionResin VolumeParticle Size (µm)   Price
21804TOYOPEARL MegaCap II SP-550EC100 mL200  195
21805TOYOPEARL MegaCap II SP-550EC250 mL200  446
21806TOYOPEARL MegaCap II SP-550EC1 L200  -
21807TOYOPEARL MegaCap II SP-550EC5 L200  -
21808TOYOPEARL MegaCap II SP-550EC50 L200  -

Product Attributes

Base bead: HW-55
Pore size (mean): 50 nm
Particle size (mean): 200 µm
Ligand type: strong cation
Ligand pKa: 1.2
DBC: 60 - 90 g/L
Pressure rating: 0.3 MPa
Shipping buffer: 20% ethanol
pH stability: 2-13
Shelf life: 10 years




Code #DescriptionLiterature Type
IM02 Instruction Manual for TOYOPEARL and TSKgel PW-type ResinsInstruction Manual
PCAT02 TOYOPEARL, TSKgel and Ca⁺⁺Pure-HA Bulk Resin 2019 Product Guide -- Ion ExchangeProduct Catalog
RIS0025 TOYOPEARL MegaCap-II-SP-550ECResin Information Sheet
P/NDescriptionPrice ($) 
21870ToyoScreen MegaCap II SP-550EC, 1 mL (qty. 6)160
21871ToyoScreen MegaCap II SP-550EC, 5 mL (qty. 6)334